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Biofilm

A closer look at the biofilms challenge

Biofilms are aggregates of microorganisms (e.g. bacteria) embedded in a slime-like matrix, which shelter the bacteria from the immune system and the effects of antimicrobials (e.g. antibiotics). *3,4 Biofilms have been observed in various conditions, such as chronic wounds, cystic fibrosis and eczema. *7,8 Conventional antibiotics for managing these infections are not effective in eradicating biofilms without having adverse effects on the host and the environment. The inappropriate use of antibiotics, and their inability to eradicate biofilms, further contributes to the development of antimicrobial resistance, and places patients at high risk for acquiring or spreading multi-drug resistant microorganisms.

There is growing evidence showing the presence of biofilms in non-healing, chronic wounds and their adverse role in delaying normal wound healing. *5,6 Current approaches for managing infections in wounds, such as antibiotics or antiseptics, are not effective in eradicating biofilm infections. To be truly effective, antimicrobial agents must be able to penetrate and kill microbes embedded in biofilms of wounds without impeding the wound healing process of the host.

Thomas Bjarnsholt, DMSc. and Professor at Copenhagen University and University Hospital has together with his partner MD Klaus Kirketerp-Møller, Chief Surgeon at Bispebjerg University Hospital and Copenhagen University, tested our antimicrobial agent and states the following;

“We have tested all known topical antiseptics for eradication and removing of biofilm, in our in-vitro wound models. SoftOx has shown outstanding results; both directly on the surface of the biofilm, and beneath the simulated wound surface where the type of biofilm is found which is the most difficult to eradicate.”

“Biofilms represent a major problem for wound healing as they protect, spread and facilitate the creation of new antibiotic-resistant superbugs.” 

Thomas Bjarnsholt, DMSc. and professor at Copenhagen University and University Hospital

Main issues of the

Biofilms challenge

Microbes (i.e. bacteria, fungi) become up to a thousand times more tolerant in biofilms.

Microbes can share and modify their resistance genes and become superbugs.

Abnormal wound healing is in part caused by inefficient eradication of infecting, opportunistic pathogens – and the wound often becomes chronic.

Antibiotics, antiseptics and the immune system are prevented from working.